Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

H J Mackay, D Cameron, M Rahilly, M J Mackean, J Paul, S B Kaye, R Brown

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival.
Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalJournal of Clinical Oncology
Volume18
Issue number1
Publication statusPublished - Jan 2000

Keywords

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • Antineoplastic Agents
  • Base Pair Mismatch
  • Breast Neoplasms
  • Carrier Proteins
  • Disease-Free Survival
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Likelihood Functions
  • Middle Aged
  • Neoplasm Proteins
  • Nuclear Proteins
  • Prognosis
  • Regression Analysis
  • Retrospective Studies
  • Statistics, Nonparametric
  • Tumor Suppressor Protein p53

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