Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

H J Mackay; D Cameron; M Rahilly; M J Mackean; J Paul; S B Kaye; R Brown

Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

H J Mackay, D Cameron, M Rahilly, M J Mackean, J Paul, S B Kaye, R Brown

Research output: Contribution to journal › Article › peer-review

Abstract

Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival.

Original language	English
Pages (from-to)	87-93
Number of pages	7
Journal	Journal of Clinical Oncology
Volume	18
Issue number	1
Publication status	Published - Jan 2000

Keywords / Materials (for Non-textual outputs)

Adaptor Proteins, Signal Transducing
Adult
Aged
Antineoplastic Agents
Base Pair Mismatch
Breast Neoplasms
Carrier Proteins
Disease-Free Survival
Drug Resistance, Neoplasm
Female
Humans
Likelihood Functions
Middle Aged
Neoplasm Proteins
Nuclear Proteins
Prognosis
Regression Analysis
Retrospective Studies
Statistics, Nonparametric
Tumor Suppressor Protein p53

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title = "Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival",

abstract = "Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival.",

keywords = "Adaptor Proteins, Signal Transducing, Adult, Aged, Antineoplastic Agents, Base Pair Mismatch, Breast Neoplasms, Carrier Proteins, Disease-Free Survival, Drug Resistance, Neoplasm, Female, Humans, Likelihood Functions, Middle Aged, Neoplasm Proteins, Nuclear Proteins, Prognosis, Regression Analysis, Retrospective Studies, Statistics, Nonparametric, Tumor Suppressor Protein p53",

author = "Mackay, {H J} and D Cameron and M Rahilly and Mackean, {M J} and J Paul and Kaye, {S B} and R Brown",

year = "2000",

month = jan,

language = "English",

volume = "18",

pages = "87--93",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "American Society of Clinical Oncology",

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}

TY - JOUR

T1 - Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

AU - Mackay, H J

AU - Cameron, D

AU - Rahilly, M

AU - Mackean, M J

AU - Paul, J

AU - Kaye, S B

AU - Brown, R

PY - 2000/1

Y1 - 2000/1

N2 - Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival.

AB - Loss of function or expression of the mismatch repair protein MLH1 and the tumor suppressor protein p53 have been implicated in acquired resistance to anticancer drugs. We have compared the expression of MLH1 and p53 in tumors from women with clinically node-positive breast cancer before and after primary (neoadjuvant) chemotherapy. Further, we have assessed the value of these markers as predictors of response to therapy by correlation with disease-free survival.

KW - Adaptor Proteins, Signal Transducing

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Base Pair Mismatch

KW - Breast Neoplasms

KW - Carrier Proteins

KW - Disease-Free Survival

KW - Drug Resistance, Neoplasm

KW - Female

KW - Humans

KW - Likelihood Functions

KW - Middle Aged

KW - Neoplasm Proteins

KW - Nuclear Proteins

KW - Prognosis

KW - Regression Analysis

KW - Retrospective Studies

KW - Statistics, Nonparametric

KW - Tumor Suppressor Protein p53

M3 - Article

C2 - 10623697

SN - 0732-183X

VL - 18

SP - 87

EP - 93

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 1

ER -

Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival

Abstract

Keywords / Materials (for Non-textual outputs)

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