Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein

M R Macleod, L Ramage, A McGregor, J R Seckl

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Apoptosis is an important route to neuronal death in experimental models of stroke, the leading neurological cause of death and disability. Here we explore a role for ataxia telangiectasia mutated protein (ATM), an activator of p53, in a primary cortical culture model of stroke. NMDA-induced apoptosis was reduced in cultures derived from mice with targeted deletions in the ATM gene. In addition, NMDA-induced caspase-3 activity was abolished in cultures lacking two functioning copies of the ATM gene. These data provide evidence to suggest that, in primary cortical culture, NMDA-induced apoptosis is partially mediated through ATM. They provide further evidence to support the hypothesis that DNA damage is one route to apoptosis following neuronal injury.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
Issue number2
Publication statusPublished - 10 Feb 2003


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