Reducing the toll of inflammatory lung disease

Nazia Chaudhuri, Moira K. B. Whyte, Ian Sabroe*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Toll-like receptors (TLRs) are pivotal in human response to microbial stimuli. Their activation and signaling underpin much of the observed epidemiologic data generated by the hygiene hypothesis, and their contribution to infectious exacerbations of airways disease is likely to be highly important. Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity.

Original languageEnglish
Pages (from-to)1550-1556
Number of pages7
JournalChest
Volume131
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • hygiene
  • infection
  • Toll-like receptor
  • treatment
  • INNATE IMMUNE-SYSTEM
  • CELL WALL COMPONENTS
  • REGULATORY T-CELLS
  • NF-KAPPA-B
  • CUTTING EDGE
  • RECEPTOR 4
  • DENDRITIC CELLS
  • BACTERIAL-INFECTIONS
  • CHLAMYDIA-PNEUMONIAE
  • SMOOTH-MUSCLE

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