Reduction by NG-nitro-L-arginine methyl ester (L-NAME) of antigen-induced nasal airway plasma extravasation in human subjects in vivo

J W Dear, G K Scadding, J C Foreman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In non-allergic subjects, histamine induced a reduction of minimal nasal cross-sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), 1 mumol but not by D-NAME, 1 mumol. L-NAME, 1 and 10 mumol, did not inhibit the histamine-induced reduction of Amin. In subjects allergic to grass pollen, antigen challenge induced a reduction in Amin that was not changed by pretreatment with L-NAME, and an increase in albumin release that was inhibited by L-NAME, 1 mumol. The data support a role for nitric oxide in mediating plasma extravasation in the nose induced by antigen challenge or histamine.

Original languageEnglish
Pages (from-to)1720-2
Number of pages3
JournalBritish Journal of Pharmacology
Volume116
Issue number2
Publication statusPublished - Sept 1995

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Albumins
  • Antigens
  • Arginine
  • Enzyme Inhibitors
  • Extravasation of Diagnostic and Therapeutic Materials
  • Histamine
  • Humans
  • Middle Aged
  • NG-Nitroarginine Methyl Ester
  • Nasal Cavity
  • Rhinitis, Allergic, Seasonal
  • Sodium Chloride

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