Reductional meiosis I chromosome segregation is established by coordination of key meiotic kinases

Stefan Galander, Rachael Barton, Weronika E. Borek, Christos Spanos, David A. Kelly, Daniel Robertson, Juri Rappsilber, Adèle L. Marston

Research output: Contribution to journalArticlepeer-review

Abstract

Meiosis produces gametes through a specialised, two-step cell division, which is highly error-prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where sister chromatids separate. Uniquely during meiosis I, sister kinetochores are monooriented and pericentromeric cohesin is protected. Here we demonstrate that these key adaptations for reductional chromosome segregation are achieved through separable control of multiple kinases by the meiosis I-specific budding yeast Spo13 protein. Recruitment of Polo kinase to kinetochores directs monoorientation, while, independently, cohesin protection is achieved by containing the effects of cohesin kinases. Therefore, reductional chromosome segregation, the defining feature of meiosis, is established by multifaceted kinase control by a master regulator. The recent identification of Spo13 orthologs, fission yeast Moa1 and mouse MEIKIN, suggests that kinase coordination by a meiosis I regulator may be a general feature in the establishment of reductional chromosome segregation.
Original languageEnglish
Pages (from-to)526-541.e5
Number of pages22
JournalDevelopmental Cell
Volume49
Issue number4
Early online date25 Apr 2019
DOIs
Publication statusPublished - 20 May 2019

Keywords

  • DDK
  • Hrr25
  • Polo kinase
  • Spo13
  • chromosome segregation
  • cohesin
  • kinetochore
  • meiosis
  • monoorientation
  • shugoshin

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