Regenerating CNS myelin - From mechanisms to experimental medicines

Robin J.M. Franklin, Charles Ffrench-Constant

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Although the core concept of remyelination - based on the activation, migration, proliferation and differentiation of CNS progenitors - has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably. We can now decorate the central events of remyelination with a host of pathways, molecules, mediators and cells, revealing a complex and precisely orchestrated process. These advances have led to recent drug-based and cell-based clinical trials for myelin diseases and have opened up hitherto unrecognized opportunities for drug-based approaches to therapeutically enhance remyelination.

Original languageEnglish
Pages (from-to)753-769
Number of pages17
JournalNature Reviews Neuroscience
Volume18
Issue number12
Early online date16 Nov 2017
DOIs
Publication statusE-pub ahead of print - 16 Nov 2017

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