Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors

William C. W. Chen*, Bruno Peault, Johnny Huard

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascular/perivascular niches. Using immunohistochemistry and fluorescence-activated cell sorting, we and other groups have prospectively identified and purified subpopulations of multipotent precursor cells associated with the blood vessels within multiple human organs. The three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia. MECs, PCs, and ACs have been extensively characterized in prior studies and are currently under investigation for their therapeutic potentials in preclinical animal models. In this review, we will briefly discuss the identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) and summarize the current status of regenerative applications of hBVSC subsets.

Original languageEnglish
Article number375187
Number of pages11
JournalStem Cells International
DOIs
Publication statusPublished - May 2015

Keywords

  • MESENCHYMAL STEM-CELLS
  • HUMAN SKELETAL-MUSCLE
  • MYOGENIC ENDOTHELIAL-CELLS
  • RESIDENT PROGENITOR CELLS
  • HUMAN ADIPOSE-TISSUE
  • PERICYTE-LIKE CELLS
  • VASCULAR WALL
  • PERIVASCULAR CELLS
  • SATELLITE CELLS
  • STROMAL CELLS

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