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Abstract
Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Early MAT formation in mice is conserved, whereas later development is strain dependent. Proximal, but not distal tibial, MAT is lost with 21-day cold exposure. Rat MAT adipocytes from distal sites have an increased proportion of monounsaturated fatty acids and expression of Scd1/Scd2, Cebpa and Cebpb. Humans also have increased distal marrow fat unsaturation. We define proximal ‘regulated’ MAT (rMAT) as single adipocytes interspersed with active haematopoiesis, whereas distal ‘constitutive’ MAT (cMAT) has low haematopoiesis, contains larger adipocytes, develops earlier and remains preserved upon systemic challenges. Loss of rMAT occurs in mice with congenital generalized lipodystrophy type 4, whereas both rMAT and cMAT are preserved in mice with congenital generalized lipodystrophy type 3. Consideration of these MAT subpopulations may be important for future studies linking MAT to bone biology, haematopoiesis and whole-body metabolism.
Original language | English |
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Article number | 7808 |
Number of pages | 15 |
Journal | Nature Communications |
Volume | 6 |
DOIs | |
Publication status | Published - 6 Aug 2015 |
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Endocrine and Metabolic Functions of Bone Marrow Adipose Tissue
Cawthorn, W. (Invited speaker)
1 Dec 2018Activity: Academic talk or presentation types › Invited talk
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Basic research on Bone and Cartilage biology
Cawthorn, W. (Invited speaker)
5 Oct 2017 → 6 Oct 2017Activity: Participating in or organising an event types › Participation in conference
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Endocrine Club Seminar: "Bone Marrow Adipose Tissue: Starving for Attention"
Cawthorn, W. (Invited speaker)
20 Feb 2017Activity: Academic talk or presentation types › Invited talk
Profiles
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William Cawthorn
- Deanery of Clinical Sciences - Senior Lecturer
- Centre for Cardiovascular Science
Person: Academic: Research Active