We use satellite observations of aerosol optical depth τ and cloud effective radius r from the ATSR-2 instrument in 1997 to investigate the Twomey indirect effect (IE, -∂ 1n r/∂ 1n τ ) in regions of continental outflow. We generally find a negative correlation between τ and r, with the strongest inverse relationships downwind of Africa. North American and eastern Asian continental outflow exhibits a strong seasonal dependence, as expected. Global values for IE range from 0.10 to 0.16, consistent with theoretical predictions. Downwind of Africa, we find that the IE is unphysically high but robust (r = -0.85) during JJA associated with high aerosol loading, and attribute this tentatively to the Twomey hypothesis accounting only for a limited number of physical properties of aerosols.