Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome

Christopher, M. Orrett; N. Deeb; Ricardo Pong-Wong; Oswald Matika; C. R. G. Lewis; D. G. McLaren; Alan Archibald; Stephen Bishop

Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome

Christopher, M. Orrett, N. Deeb, Ricardo Pong-Wong, Oswald Matika, C. R. G. Lewis, D. G. McLaren, Alan Archibald, Stephen Bishop

Royal (Dick) School of Veterinary Studies

Research output: Contribution to conference › Paper

Abstract

Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h²) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.

Original language	English
Pages	100
Publication status	Published - 2014
Event	Proceedings, 10 th World Congress of Genetics Applied to Livestock Production - Canada, Vancouver, Canada Duration: 17 Aug 2014 → 22 Aug 2014

Conference

Conference	Proceedings, 10 th World Congress of Genetics Applied to Livestock Production
Country/Territory	Canada
City	Vancouver
Period	17/08/14 → 22/08/14

Keywords / Materials (for Non-textual outputs)

Pig
PRRS
Regional Heritability Mapping

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https://asas.org/docs/default-source/wcgalp-proceedings-oral/100_paper_6916_manuscript_387_0.pdf?sfvrsn=2

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Orrett, C. M., Deeb, N., Pong-Wong, R., Matika, O., Lewis, C. R. G., McLaren, D. G., Archibald, A., & Bishop, S. (2014). Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome. 100. Paper presented at Proceedings, 10 th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada. https://asas.org/docs/default-source/wcgalp-proceedings-oral/100_paper_6916_manuscript_387_0.pdf?sfvrsn=2

@conference{24159a91e365405d88cac288c28173e5,

title = "Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome",

abstract = "Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h2) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.",

keywords = "Pig, PRRS, Regional Heritability Mapping",

author = "Orrett, \{Christopher, M.\} and N. Deeb and Ricardo Pong-Wong and Oswald Matika and Lewis, \{C. R. G.\} and McLaren, \{D. G.\} and Alan Archibald and Stephen Bishop",

year = "2014",

language = "English",

pages = "100",

note = "Proceedings, 10 th World Congress of Genetics Applied to Livestock Production ; Conference date: 17-08-2014 Through 22-08-2014",

}

Orrett, CM, Deeb, N, Pong-Wong, R , Matika, O, Lewis, CRG, McLaren, DG, Archibald, A & Bishop, S 2014, 'Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome', Paper presented at Proceedings, 10 th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 17/08/14 - 22/08/14 pp. 100. <https://asas.org/docs/default-source/wcgalp-proceedings-oral/100_paper_6916_manuscript_387_0.pdf?sfvrsn=2>

TY - CONF

T1 - Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome

AU - Orrett, Christopher, M.

AU - Deeb, N.

AU - Pong-Wong, Ricardo

AU - Matika, Oswald

AU - Lewis, C. R. G.

AU - McLaren, D. G.

AU - Archibald, Alan

AU - Bishop, Stephen

PY - 2014

Y1 - 2014

N2 - Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h2) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.

AB - Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h2) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.

KW - Pig

KW - PRRS

KW - Regional Heritability Mapping

M3 - Paper

SP - 100

T2 - Proceedings, 10 th World Congress of Genetics Applied to Livestock Production

Y2 - 17 August 2014 through 22 August 2014

ER -

Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome

Abstract

Conference

Keywords / Materials (for Non-textual outputs)

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