Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

J S Chamberlain; S G Grant; A A Reeves; L J Mullins; D A Stephenson; E P Hoffman; A P Monaco; L M Kunkel; C T Caskey; V M Chapman

Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

J S Chamberlain, S G Grant, A A Reeves, L J Mullins, D A Stephenson, E P Hoffman, A P Monaco, L M Kunkel, C T Caskey, V M Chapman

Research output: Contribution to journal › Article › peer-review

Abstract

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

Original language	English
Pages (from-to)	671-8
Number of pages	8
Journal	Somatic Cell and Molecular Genetics
Volume	13
Issue number	6
Publication status	Published - Nov 1987

Keywords

Animals
Chromosome Mapping
DNA
Disease Models, Animal
Genetic Linkage
Humans
Mice
Muscular Dystrophy, Animal
Mutation
Nucleic Acid Hybridization
Polymorphism, Restriction Fragment Length
Species Specificity
X Chromosome

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title = "Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome",

abstract = "The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.",

keywords = "Animals, Chromosome Mapping, DNA, Disease Models, Animal, Genetic Linkage, Humans, Mice, Muscular Dystrophy, Animal, Mutation, Nucleic Acid Hybridization, Polymorphism, Restriction Fragment Length, Species Specificity, X Chromosome",

author = "Chamberlain, {J S} and Grant, {S G} and Reeves, {A A} and Mullins, {L J} and Stephenson, {D A} and Hoffman, {E P} and Monaco, {A P} and Kunkel, {L M} and Caskey, {C T} and Chapman, {V M}",

year = "1987",

month = nov,

language = "English",

volume = "13",

pages = "671--8",

journal = "Somatic Cell and Molecular Genetics",

issn = "0740-7750",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

number = "6",

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TY - JOUR

T1 - Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

AU - Chamberlain, J S

AU - Grant, S G

AU - Reeves, A A

AU - Mullins, L J

AU - Stephenson, D A

AU - Hoffman, E P

AU - Monaco, A P

AU - Kunkel, L M

AU - Caskey, C T

AU - Chapman, V M

PY - 1987/11

Y1 - 1987/11

N2 - The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

AB - The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

KW - Animals

KW - Chromosome Mapping

KW - DNA

KW - Disease Models, Animal

KW - Genetic Linkage

KW - Humans

KW - Mice

KW - Muscular Dystrophy, Animal

KW - Mutation

KW - Nucleic Acid Hybridization

KW - Polymorphism, Restriction Fragment Length

KW - Species Specificity

KW - X Chromosome

M3 - Article

C2 - 2890215

VL - 13

SP - 671

EP - 678

JO - Somatic Cell and Molecular Genetics

JF - Somatic Cell and Molecular Genetics

SN - 0740-7750

IS - 6

ER -

Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

Abstract

Keywords

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