Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

J S Chamberlain, S G Grant, A A Reeves, L J Mullins, D A Stephenson, E P Hoffman, A P Monaco, L M Kunkel, C T Caskey, V M Chapman

Research output: Contribution to journalArticlepeer-review


The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

Original languageEnglish
Pages (from-to)671-8
Number of pages8
JournalSomatic Cell and Molecular Genetics
Issue number6
Publication statusPublished - Nov 1987


  • Animals
  • Chromosome Mapping
  • DNA
  • Disease Models, Animal
  • Genetic Linkage
  • Humans
  • Mice
  • Muscular Dystrophy, Animal
  • Mutation
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length
  • Species Specificity
  • X Chromosome


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