Regioselective coupling reactions of 2,4-diaminopyridine derivatives with aryl halides: the synthesis of elaborated pyridines

M.M. Bio, E. Cleator, A.J. Davies, S.E. Hamilton, A. Lawrence, F.J. Sheen, G.W. Stewart, R.D. Wilson, Andrew Lawrence

Research output: Contribution to journalArticlepeer-review

Abstract

The development of a synthetically useful, regioselective cross-coupling of 2,4-diaminopyridines with aryl and heteroaryl halides is reported. Selectivity for coupling through either amine is controlled by a simple change in the reaction conditions. Cross-coupling through the 2-amino group predominates in the presence of a palladium catalyst, whilst the 4-amino coupled product predominates in the absence of palladium.
Original languageEnglish
Pages (from-to)8950-8955
Number of pages6
JournalTetrahedron
Volume65
Issue number44
DOIs
Publication statusPublished - 31 Oct 2009

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