Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes

Kevin Robertson, E J Usherwood, Anthony Nash

Research output: Contribution to journalArticlepeer-review

Abstract

Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.
Original languageEnglish
Pages (from-to)3480-2
Number of pages3
JournalJournal of Virology
Volume75
Issue number7
DOIs
Publication statusPublished - 2001

Keywords

  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cytokines
  • Female
  • Gammaherpesvirinae
  • Immunotherapy, Adoptive
  • Lymphoma, B-Cell
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude

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