Regulating the regulator: Nitric oxide control of post‐translational modifications

Jagadis Gupta Kapuganti, Zsuzsanna. Kolbert, Jorg Durner, Christian Lindermayr, Francisco J. Corpas, Renaud Brouquisse, Juan B. Barroso, Saima Umbreen, José M. Palma, John T. Hancock, Marek Petrivalsky, David Wendehenne, Gary J. Loake

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) is perfectly suited for duties as a redox signalling molecule. A key route for NO
bioactivity occurs via protein S-nitrosation, the addition of a NO moiety to a protein cysteine
(Cys) thiol (-SH) to form a S-nitrosothiol (SNO). This process is thought to underpin a myriad of
cellular processes in plants linked to development, environmental responses and immune function.
Here we collate emerging evidence showing that NO bioactivity regulates a growing number of
diverse post-translational modifications (PTMs) including SUMOylation, phosphorylation,
persulfidation and acetylation. We provide examples of how NO orchestrates these processes to
mediate plant adaptation to a variety of cellular cues.
Original languageEnglish
JournalNew Phytologist
DOIs
Publication statusPublished - 27 Apr 2020

Keywords

  • nitric oxide
  • phosphorylation
  • s-nitrosation
  • SUMOylation
  • S-nitrosylation
  • persulfidation
  • reactive nitrogen species (RNS)
  • reactive oxygen species (ROS)

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