Abstract / Description of output
Human cytomegalovirus (HCMV) may opportunistically use retinoic acid (RA), a physiologically essential control molecule of cellular differentiation, to advance its own replication. At present, it is not clear whether RA stimulation of HCMV replication is exclusively a differentiation driven event. We report that exposure of permissively infected primary human foreskin fibroblast cells to RA transcriptionally activates the viral major immediate-early promoter (MIEP) and enhances the production of infectious particles. These experiments implicate a direct involvement of RA in modulating HCMV activation.
| Original language | English |
|---|---|
| Pages (from-to) | 113-5 |
| Number of pages | 3 |
| Journal | Scandinavian Journal of Infectious Diseases, Supplement |
| Volume | 99 |
| Publication status | Published - 1995 |
Keywords / Materials (for Non-textual outputs)
- Cytomegalovirus
- Humans
- Tretinoin
- Virus Replication