TY - JOUR
T1 - Regulation of Listeria virulence: PrfA master and commander
AU - de las Heras, Aitor
AU - Cain, Robert J.
AU - Bieleckal, Magdalena K.
AU - Vazquez-Boland, Jose A.
PY - 2011/4
Y1 - 2011/4
N2 - Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection. These bacteria live as soil saprotrophs on decaying plant matter but also as intracellular parasites, using the cell cytosol as a replication niche. PrfA, a regulatory protein, integrates a number of environmental cues that signal the transition between these two contrasting lifestyles, activating a set of key virulence factors during host infection. While a number of details concerning the general mode of action of this virulence master switch have been elucidated, others remain unsolved. Recent work has revealed additional mechanisms that contribute to L. monocytogenes virulence modulation, often via cross-talk with PrfA, or by regulating new genes involved in host colonization.
AB - Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection. These bacteria live as soil saprotrophs on decaying plant matter but also as intracellular parasites, using the cell cytosol as a replication niche. PrfA, a regulatory protein, integrates a number of environmental cues that signal the transition between these two contrasting lifestyles, activating a set of key virulence factors during host infection. While a number of details concerning the general mode of action of this virulence master switch have been elucidated, others remain unsolved. Recent work has revealed additional mechanisms that contribute to L. monocytogenes virulence modulation, often via cross-talk with PrfA, or by regulating new genes involved in host colonization.
UR - http://www.scopus.com/inward/record.url?scp=79954627408&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2011.01.005
DO - 10.1016/j.mib.2011.01.005
M3 - Literature review
VL - 14
SP - 118
EP - 127
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 2
ER -