Regulation of methanol and methylamine dehydrogenases in Methylophilus methylotrophus

A. Dawson, G. Southgate, P. M. Goodwin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Methylophilus methylotrophus can use methylamine as sole source of carbon and nitrogen. Measurements of the specific activity of methylamine dehydrogenase (MNDH) in bacteria grown in batch or chemostat culture showed that MNDH was induced by methylamine and repressed when methanol or NH4+ were provided as alternative carbon or nitrogen sources. The degree of repression varied with the growth conditions. Methanol dehydrogenase (MDH) was present in bacteria growtn on methylamine as sole carbon source, but the specific activity was low compared with that in bacteria grown on medium containing methanol, indicating that this enzyme is induced by methanol.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalFEMS Microbiology Letters
Issue number1-2
Publication statusPublished - 1 Mar 1990


  • Methanol dehydrogenase
  • Methylamine dehydrogenase
  • Methylophilus methylotrophus


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