Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs?

Sander van den Driesche; Richard M Sharpe; Philippa T K Saunders; Rod T Mitchell

doi:10.1016/j.semcdb.2014.04.006

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs?

Sander van den Driesche, Richard M Sharpe, Philippa T K Saunders, Rod T Mitchell

Research output: Contribution to journal › Literature review › peer-review

Abstract

Within the testis the spermatogonial stem cells reside in a unique microenvironment, or 'niche', which includes the surrounding somatic cells. The regulation of the balance between self-renewal and differentiation of spermatogonial stem cells determines the lifelong supply of spermatozoa by maintaining a population of undifferentiated spermatogonial stem cells and ensuring that adequate numbers of spermatogonia undergo spermatogenesis. Mouse models have been instrumental in determining a large number of factors involved in regulating the spermatogonial stem cell self-renewal and/or differentiation. However, the precise mechanisms controlling regulation of the germ cell niche remain to be elucidated. Recently the discovery of microRNAs, which regulate gene expression at the post-transcriptional level, has provided new insight into testis biology, spermatogenesis and germ stem cell regulation. In this review we summarize the main factors involved in the regulation of the germ stem cell niche and describe the role of microRNA signaling in this regulation.

Original language	English
Pages (from-to)	76-83
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	29C
Early online date	6 Apr 2014
DOIs	https://doi.org/10.1016/j.semcdb.2014.04.006
Publication status	Published - May 2014

Keywords / Materials (for Non-textual outputs)

MicroRNA
Niche
SELF-RENEWAL
Sertoli cell
Spermatogonial stem cell
TESTIS

Access to Document

10.1016/j.semcdb.2014.04.006

Supplementary material - figure 1Accepted author manuscript, 877 KB
Supplementary material - figure 2Accepted author manuscript, 851 KB
Regulation of the germ stem cell niche as the foundation for adult spermatogenesis
This a PDF file of an unedited manuscript that has been accepted for publication. The final author version is available here: http://www.sciencedirect.com/science/article/pii/S1084952114000779
Accepted author manuscript, 308 KB

http://www.sciencedirect.com/science/article/pii/S1084952114000779

Intermediate Clinical Fellowship - The germ stem cell niche in the human testis and the origins of Testicular Cancer
Mitchell, R. (Principal Investigator)
UK-based charities
1/10/12 → 31/03/17
Project: Research
Testis development and function in relation to disorders of reproductive and general health in males
Sharpe, R. (Principal Investigator)
MRC
1/10/11 → 30/09/16
Project: Research

Cite this

@article{f8ab42e7aa5841419b6c8dec911a1fc5,

title = "Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs?",

abstract = "Within the testis the spermatogonial stem cells reside in a unique microenvironment, or 'niche', which includes the surrounding somatic cells. The regulation of the balance between self-renewal and differentiation of spermatogonial stem cells determines the lifelong supply of spermatozoa by maintaining a population of undifferentiated spermatogonial stem cells and ensuring that adequate numbers of spermatogonia undergo spermatogenesis. Mouse models have been instrumental in determining a large number of factors involved in regulating the spermatogonial stem cell self-renewal and/or differentiation. However, the precise mechanisms controlling regulation of the germ cell niche remain to be elucidated. Recently the discovery of microRNAs, which regulate gene expression at the post-transcriptional level, has provided new insight into testis biology, spermatogenesis and germ stem cell regulation. In this review we summarize the main factors involved in the regulation of the germ stem cell niche and describe the role of microRNA signaling in this regulation.",

keywords = "MicroRNA, Niche, SELF-RENEWAL, Sertoli cell, Spermatogonial stem cell, TESTIS",

author = "{van den Driesche}, Sander and Sharpe, {Richard M} and Saunders, {Philippa T K} and Mitchell, {Rod T}",

year = "2014",

month = may,

doi = "10.1016/j.semcdb.2014.04.006",

language = "English",

volume = "29C",

pages = "76--83",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier",

}

TY - JOUR

T1 - Regulation of the germ stem cell niche as the foundation for adult spermatogenesis

T2 - A role for miRNAs?

AU - van den Driesche, Sander

AU - Sharpe, Richard M

AU - Saunders, Philippa T K

AU - Mitchell, Rod T

PY - 2014/5

Y1 - 2014/5

N2 - Within the testis the spermatogonial stem cells reside in a unique microenvironment, or 'niche', which includes the surrounding somatic cells. The regulation of the balance between self-renewal and differentiation of spermatogonial stem cells determines the lifelong supply of spermatozoa by maintaining a population of undifferentiated spermatogonial stem cells and ensuring that adequate numbers of spermatogonia undergo spermatogenesis. Mouse models have been instrumental in determining a large number of factors involved in regulating the spermatogonial stem cell self-renewal and/or differentiation. However, the precise mechanisms controlling regulation of the germ cell niche remain to be elucidated. Recently the discovery of microRNAs, which regulate gene expression at the post-transcriptional level, has provided new insight into testis biology, spermatogenesis and germ stem cell regulation. In this review we summarize the main factors involved in the regulation of the germ stem cell niche and describe the role of microRNA signaling in this regulation.

AB - Within the testis the spermatogonial stem cells reside in a unique microenvironment, or 'niche', which includes the surrounding somatic cells. The regulation of the balance between self-renewal and differentiation of spermatogonial stem cells determines the lifelong supply of spermatozoa by maintaining a population of undifferentiated spermatogonial stem cells and ensuring that adequate numbers of spermatogonia undergo spermatogenesis. Mouse models have been instrumental in determining a large number of factors involved in regulating the spermatogonial stem cell self-renewal and/or differentiation. However, the precise mechanisms controlling regulation of the germ cell niche remain to be elucidated. Recently the discovery of microRNAs, which regulate gene expression at the post-transcriptional level, has provided new insight into testis biology, spermatogenesis and germ stem cell regulation. In this review we summarize the main factors involved in the regulation of the germ stem cell niche and describe the role of microRNA signaling in this regulation.

KW - MicroRNA

KW - Niche

KW - SELF-RENEWAL

KW - Sertoli cell

KW - Spermatogonial stem cell

KW - TESTIS

U2 - 10.1016/j.semcdb.2014.04.006

DO - 10.1016/j.semcdb.2014.04.006

M3 - Literature review

C2 - 24718319

SN - 1084-9521

VL - 29C

SP - 76

EP - 83

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: A role for miRNAs?

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Intermediate Clinical Fellowship - The germ stem cell niche in the human testis and the origins of Testicular Cancer

Testis development and function in relation to disorders of reproductive and general health in males

Cite this