Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain

Research output: Contribution to journalArticlepeer-review

Abstract

Early in mammalian brain development cell proliferation generates a population of progenitor cells whose subsequent divisions produce increasing numbers of postmitotic neurons. Pax6 affects both processes and it has been suggested that this changing role is due at least in part to changes in the relative concentrations of its two main isoforms, (i) Pax6 and (ii) Pax6(5a), created by insertion of a 42 bp exon (exon 5a) into one of the two DNA-binding domains. Crucially, however, no previous study has determined whether the ratio between Pax6 and Pax6(5a) transcripts alters during mammalian neurogenesis in vivo.
Original languageEnglish
Article number13
Number of pages4
JournalBMC Developmental Biology
Volume5
DOIs
Publication statusPublished - 2005

Fingerprint

Dive into the research topics of 'Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain'. Together they form a unique fingerprint.

Cite this