Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

Ana Tufegdžić Vidaković; Richard Mitter; Gavin P. Kelly; Michelle Neumann; Michelle Harreman; Marta Rodríguez-Martínez; Anna Herlihy; Juston C. Weems; Stefan Boeing; Vesela Encheva; Liam Gaul; Laura Milligan; David Tollervey; Ronald C. Conaway; Joan W. Conaway; Ambrosius P. Snijders; Aengus Stewart; Jesper Q. Svejstrup

doi:10.1016/j.cell.2020.02.009

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

Ana Tufegdžić Vidaković, Richard Mitter, Gavin P. Kelly, Michelle Neumann, Michelle Harreman, Marta Rodríguez-Martínez, Anna Herlihy, Juston C. Weems, Stefan Boeing, Vesela Encheva, Liam Gaul, Laura Milligan, David Tollervey, Ronald C. Conaway, Joan W. Conaway, Ambrosius P. Snijders, Aengus Stewart, Jesper Q. Svejstrup^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.

Original language	English
Pages (from-to)	1245-1261.e21
Journal	Cell
Volume	180
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2020.02.009
Publication status	Published - 5 Mar 2020

Keywords / Materials (for Non-textual outputs)

DNA damage
RNA polymerase II
transcription
ubiquitin
ubiquitylation
UV irradiation

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10.1016/j.cell.2020.02.009Licence: Creative Commons: Attribution (CC-BY)

SvejstrupEtalCP2020RegulationOfTheRNAPIIPoolIsIntegralFinal published version, 7.72 MBLicence: Creative Commons: Attribution (CC-BY)

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Tufegdžić Vidaković, A., Mitter, R., Kelly, G. P., Neumann, M., Harreman, M., Rodríguez-Martínez, M., Herlihy, A., Weems, J. C., Boeing, S., Encheva, V., Gaul, L., Milligan, L., Tollervey, D., Conaway, R. C., Conaway, J. W., Snijders, A. P., Stewart, A., & Svejstrup, J. Q. (2020). Regulation of the RNAPII Pool Is Integral to the DNA Damage Response. Cell, 180(6), 1245-1261.e21. https://doi.org/10.1016/j.cell.2020.02.009

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title = "Regulation of the RNAPII Pool Is Integral to the DNA Damage Response",

abstract = "Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.",

keywords = "DNA damage, RNA polymerase II, transcription, ubiquitin, ubiquitylation, UV irradiation",

author = "{Tufegd{\v z}i{\'c} Vidakovi{\'c}}, Ana and Richard Mitter and Kelly, {Gavin P.} and Michelle Neumann and Michelle Harreman and Marta Rodr{\'i}guez-Mart{\'i}nez and Anna Herlihy and Weems, {Juston C.} and Stefan Boeing and Vesela Encheva and Liam Gaul and Laura Milligan and David Tollervey and Conaway, {Ronald C.} and Conaway, {Joan W.} and Snijders, {Ambrosius P.} and Aengus Stewart and Svejstrup, {Jesper Q.}",

year = "2020",

month = mar,

day = "5",

doi = "10.1016/j.cell.2020.02.009",

language = "English",

volume = "180",

pages = "1245--1261.e21",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier",

number = "6",

}

Tufegdžić Vidaković, A, Mitter, R, Kelly, GP, Neumann, M, Harreman, M, Rodríguez-Martínez, M, Herlihy, A, Weems, JC, Boeing, S, Encheva, V, Gaul, L, Milligan, L , Tollervey, D, Conaway, RC, Conaway, JW, Snijders, AP, Stewart, A & Svejstrup, JQ 2020, 'Regulation of the RNAPII Pool Is Integral to the DNA Damage Response', Cell, vol. 180, no. 6, pp. 1245-1261.e21. https://doi.org/10.1016/j.cell.2020.02.009

TY - JOUR

T1 - Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

AU - Tufegdžić Vidaković, Ana

AU - Mitter, Richard

AU - Kelly, Gavin P.

AU - Neumann, Michelle

AU - Harreman, Michelle

AU - Rodríguez-Martínez, Marta

AU - Herlihy, Anna

AU - Weems, Juston C.

AU - Boeing, Stefan

AU - Encheva, Vesela

AU - Gaul, Liam

AU - Milligan, Laura

AU - Tollervey, David

AU - Conaway, Ronald C.

AU - Conaway, Joan W.

AU - Snijders, Ambrosius P.

AU - Stewart, Aengus

AU - Svejstrup, Jesper Q.

PY - 2020/3/5

Y1 - 2020/3/5

N2 - Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.

AB - Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.

KW - DNA damage

KW - RNA polymerase II

KW - transcription

KW - ubiquitin

KW - ubiquitylation

KW - UV irradiation

U2 - 10.1016/j.cell.2020.02.009

DO - 10.1016/j.cell.2020.02.009

M3 - Article

C2 - 32142654

AN - SCOPUS:85081645943

SN - 0092-8674

VL - 180

SP - 1245-1261.e21

JO - Cell

JF - Cell

IS - 6

ER -

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

Abstract

Keywords / Materials (for Non-textual outputs)

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