Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome

S C Donnelly; C Haslett; P T Reid; I S Grant; W A Wallace; C N Metz; L J Bruce; R Bucala

Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome

S C Donnelly, C Haslett, P T Reid, I S Grant, W A Wallace, C N Metz, L J Bruce, R Bucala

Research output: Contribution to journal › Article › peer-review

Abstract

Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.

Original language	English
Pages (from-to)	320-3
Number of pages	4
Journal	Nature Medicine
Volume	3
Issue number	3
Publication status	Published - Mar 1997

Keywords

Cells, Cultured
Humans
Immunohistochemistry
Infant, Newborn
Interleukin-8
Lung
Macrophage Migration-Inhibitory Factors
Respiratory Distress Syndrome, Newborn
Tumor Necrosis Factor-alpha

Cite this

@article{a61ecbe2c7f242fe9158cbabe4c9ec33,

title = "Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome",

abstract = "Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.",

keywords = "Cells, Cultured, Humans, Immunohistochemistry, Infant, Newborn, Interleukin-8, Lung, Macrophage Migration-Inhibitory Factors, Respiratory Distress Syndrome, Newborn, Tumor Necrosis Factor-alpha",

author = "Donnelly, {S C} and C Haslett and Reid, {P T} and Grant, {I S} and Wallace, {W A} and Metz, {C N} and Bruce, {L J} and R Bucala",

year = "1997",

month = mar,

language = "English",

volume = "3",

pages = "320--3",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome

AU - Donnelly, S C

AU - Haslett, C

AU - Reid, P T

AU - Grant, I S

AU - Wallace, W A

AU - Metz, C N

AU - Bruce, L J

AU - Bucala, R

PY - 1997/3

Y1 - 1997/3

N2 - Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.

AB - Migration inhibitory factor (MIF) is known to exert significant pro-inflammatory effects and has the potential to override the anti-inflammatory action of glucocorticoids. In this study we have identified significant quantities of MIF in the alveolar airspaces of patients with acute respiratory distress syndrome (ARDS). We show in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion (TNF alpha and IL-8), anti-MIF significantly attenuates TNF alpha and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids. These findings suggest that MIF may act as a mediator sustaining the pulmonary inflammatory response in ARDS and that an anti-MIF strategy may represent a novel therapeutic approach in inflammatory diseases such as ARDS.

KW - Cells, Cultured

KW - Humans

KW - Immunohistochemistry

KW - Infant, Newborn

KW - Interleukin-8

KW - Lung

KW - Macrophage Migration-Inhibitory Factors

KW - Respiratory Distress Syndrome, Newborn

KW - Tumor Necrosis Factor-alpha

M3 - Article

C2 - 9055860

VL - 3

SP - 320

EP - 323

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 3

ER -

Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome

Abstract

Keywords

Fingerprint

Cite this