Relation of Conjugated Bilirubin Concentrations to the Presence of Coronary Artery Calcium

Ki-Chul Sung*, Jinho Shin, Young-Hyo Lim, Sarah H. Wild, Christopher D. Byrne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Whether conjugated bilirubin concentration, resulting from hepatic UDP-glucuronosyl-transferase 1 A1 activity, is associated with cardiovascular disease is unknown. Our aim was to investigate the relation between serum conjugated bilirubin concentrations and coronary artery calcium score (CACS) as a measure of preclinical atherosclerosis. Data were analyzed from an occupational cohort of 14,583 subjects who underwent a cardiac computed tomographic estimation of CACS and measurements of risk factors. Logistic regression was used to describe associations between bilirubin concentrations and CACS. The proportion of subjects with a CACS >0 (total: men = 1,351, women = 111) decreased across increasing conjugated bilirubin quartiles (men p 0 (odds ratio 0.76, 95% confidence interval 0.64 to 0.92, p = 0.004, for top vs bottom quartile). After further adjustment for estimated glomerular filtration rate, the odds ratio was 0.83 (95% confidence interval 0.69 to 0.99), p = 0.04. Exclusion of subjects with a high bilirubin (total >1.3 mg/dl) did not attenuate the association. In conclusion, there was a strong inverse and independent relation between conjugated bilirubin and CACS. The mechanism behind this association is not clear and may not be causal, but the effects of glucuronidation on cardiovascular disease risk should be tested. (C) 2013 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)1873-1879
Number of pages7
JournalAmerican Journal of Cardiology
Volume112
Issue number12
DOIs
Publication statusPublished - 15 Dec 2013

Keywords

  • SERUM BILIRUBIN
  • INSULIN-RESISTANCE
  • UGT1A1-ASTERISK-28 ALLELE
  • CARDIOVASCULAR-DISEASE
  • COMPUTED-TOMOGRAPHY
  • METABOLIC SYNDROME
  • HEART-DISEASE
  • FATTY LIVER
  • UGT1A1 GENE
  • ASSOCIATION

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