TY - JOUR
T1 - Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease
AU - Zhang, Jun-fang
AU - Lim, Hwee Fang
AU - Chappell, Francesca M.
AU - Clancy, Una
AU - Wiseman, Stewart
AU - Valdés-hernández, Maria C.
AU - Garcia, Daniela Jaime
AU - Bastin, Mark E.
AU - Doubal, Fergus N.
AU - Hewins, Will
AU - Cox, Simon R.
AU - Maniega, Susana Muñoz
AU - Thrippleton, Michael
AU - Stringer, Michael
AU - Jardine, Charlotte
AU - Mcintyre, Donna
AU - Barclay, Gayle
AU - Hamilton, Iona
AU - Kesseler, Lucy
AU - Murphy, Madeleine
AU - Perri, Carol Di
AU - Wu, Yun-cheng
AU - Wardlaw, Joanna M.
PY - 2021/6/21
Y1 - 2021/6/21
N2 - Raised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical relevance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demographics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n=44; mild stroke patients, n=105; older community-dwelling participants from Lothian birth cohort 1936, n=101). We collected detailed clinical data, scanned all subjects on the same 3T MRI scanner and 3-dimensional FLAIR sequence and developed a scale to rate IFSH. In adjusted analyses, the IFSH score increased with age (per 10-year increase; OR 1.69; 95% CI, 1.42-2.02), and perivascular spaces score in centrum semiovale in stroke patients (OR 1.73; 95% CI, 1.13-2.69). Since glymphatic CSF clearance declines with age and drains partially via the cribriform plate to the nasal lymphatics, IFSH on 3T MRI may be a non-invasive biomarker of altered CSF clearance and justifies further research in larger, more diverse samples.
AB - Raised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical relevance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demographics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n=44; mild stroke patients, n=105; older community-dwelling participants from Lothian birth cohort 1936, n=101). We collected detailed clinical data, scanned all subjects on the same 3T MRI scanner and 3-dimensional FLAIR sequence and developed a scale to rate IFSH. In adjusted analyses, the IFSH score increased with age (per 10-year increase; OR 1.69; 95% CI, 1.42-2.02), and perivascular spaces score in centrum semiovale in stroke patients (OR 1.73; 95% CI, 1.13-2.69). Since glymphatic CSF clearance declines with age and drains partially via the cribriform plate to the nasal lymphatics, IFSH on 3T MRI may be a non-invasive biomarker of altered CSF clearance and justifies further research in larger, more diverse samples.
U2 - 10.1016/j.neurobiolaging.2021.06.013
DO - 10.1016/j.neurobiolaging.2021.06.013
M3 - Article
SN - 0197-4580
VL - 106
SP - 130
EP - 138
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -