Relationship between vitamin D status and leukocytes in hospitalised cats

Helen F Titmarsh; Jennifer A Cartwright; Scott Kilpatrick; Donna Gaylor; Elspeth M Milne; Jacqueline L Berry; Nicholas X Bommer; Danielle Gunn-Moore; Nicola Reed; Ian Handel; Richard J Mellanby

doi:10.1177/1098612X15625454

Relationship between vitamin D status and leukocytes in hospitalised cats

Helen F Titmarsh, Jennifer A Cartwright, Scott Kilpatrick, Donna Gaylor, Elspeth M Milne, Jacqueline L Berry, Nicholas X Bommer, Danielle Gunn-Moore, Nicola Reed, Ian Handel, Richard J Mellanby

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVES: Vitamin D deficiency, as assessed by serum 25 hydroxyvitamin D (25[OH]D) concentrations, has been linked to markers of systemic inflammation in human and canine medicine. However, the relationship between vitamin D status and inflammation has not been previously investigated in cats. The aim of this study was to examine the relationship between serum 25(OH)D concentrations and leukocyte counts in hospitalised sick cats.

METHODS: Serum 25(OH)D concentrations and haematology profiles were measured in 170 consecutive hospitalised sick cats. A binary logistical regression model examined the relationship between serum 25(OH)D concentration, age, sex, breed and neutrophil, monocyte, eosinophil and lymphocyte counts.

RESULTS: Cats with neutrophilia had lower serum 25(OH)D concentrations than cats with neutrophil concentrations below the upper limit of the reference interval (RI). There were no differences in serum 25(OH)D concentrations in cats with monocyte, lymphocyte or eosinophil counts above their respective RI compared with cats with counts below the upper limit of the RI.

CONCLUSIONS AND RELEVANCE: Hospitalised cats with a neutrophil count above the RI had lower vitamin D status. There is a need to establish whether lower vitamin D status is a cause or consequence of increased neutrophil counts.

Original language	English
Pages (from-to)	364-369
Journal	Journal of Feline Medicine and Surgery
Volume	19
Issue number	4
Early online date	21 Jan 2016
DOIs	https://doi.org/10.1177/1098612X15625454
Publication status	Published - Apr 2017

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title = "Relationship between vitamin D status and leukocytes in hospitalised cats",

abstract = "OBJECTIVES: Vitamin D deficiency, as assessed by serum 25 hydroxyvitamin D (25[OH]D) concentrations, has been linked to markers of systemic inflammation in human and canine medicine. However, the relationship between vitamin D status and inflammation has not been previously investigated in cats. The aim of this study was to examine the relationship between serum 25(OH)D concentrations and leukocyte counts in hospitalised sick cats.METHODS: Serum 25(OH)D concentrations and haematology profiles were measured in 170 consecutive hospitalised sick cats. A binary logistical regression model examined the relationship between serum 25(OH)D concentration, age, sex, breed and neutrophil, monocyte, eosinophil and lymphocyte counts.RESULTS: Cats with neutrophilia had lower serum 25(OH)D concentrations than cats with neutrophil concentrations below the upper limit of the reference interval (RI). There were no differences in serum 25(OH)D concentrations in cats with monocyte, lymphocyte or eosinophil counts above their respective RI compared with cats with counts below the upper limit of the RI.CONCLUSIONS AND RELEVANCE: Hospitalised cats with a neutrophil count above the RI had lower vitamin D status. There is a need to establish whether lower vitamin D status is a cause or consequence of increased neutrophil counts.",

author = "Titmarsh, {Helen F} and Cartwright, {Jennifer A} and Scott Kilpatrick and Donna Gaylor and Milne, {Elspeth M} and Berry, {Jacqueline L} and Bommer, {Nicholas X} and Danielle Gunn-Moore and Nicola Reed and Ian Handel and Mellanby, {Richard J}",

note = "{\textcopyright} The Author(s) 2016.",

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doi = "10.1177/1098612X15625454",

language = "English",

volume = "19",

pages = "364--369",

journal = "Journal of Feline Medicine and Surgery",

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number = "4",

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TY - JOUR

T1 - Relationship between vitamin D status and leukocytes in hospitalised cats

AU - Titmarsh, Helen F

AU - Cartwright, Jennifer A

AU - Kilpatrick, Scott

AU - Gaylor, Donna

AU - Milne, Elspeth M

AU - Berry, Jacqueline L

AU - Bommer, Nicholas X

AU - Gunn-Moore, Danielle

AU - Reed, Nicola

AU - Handel, Ian

AU - Mellanby, Richard J

PY - 2017/4

Y1 - 2017/4

N2 - OBJECTIVES: Vitamin D deficiency, as assessed by serum 25 hydroxyvitamin D (25[OH]D) concentrations, has been linked to markers of systemic inflammation in human and canine medicine. However, the relationship between vitamin D status and inflammation has not been previously investigated in cats. The aim of this study was to examine the relationship between serum 25(OH)D concentrations and leukocyte counts in hospitalised sick cats.METHODS: Serum 25(OH)D concentrations and haematology profiles were measured in 170 consecutive hospitalised sick cats. A binary logistical regression model examined the relationship between serum 25(OH)D concentration, age, sex, breed and neutrophil, monocyte, eosinophil and lymphocyte counts.RESULTS: Cats with neutrophilia had lower serum 25(OH)D concentrations than cats with neutrophil concentrations below the upper limit of the reference interval (RI). There were no differences in serum 25(OH)D concentrations in cats with monocyte, lymphocyte or eosinophil counts above their respective RI compared with cats with counts below the upper limit of the RI.CONCLUSIONS AND RELEVANCE: Hospitalised cats with a neutrophil count above the RI had lower vitamin D status. There is a need to establish whether lower vitamin D status is a cause or consequence of increased neutrophil counts.

AB - OBJECTIVES: Vitamin D deficiency, as assessed by serum 25 hydroxyvitamin D (25[OH]D) concentrations, has been linked to markers of systemic inflammation in human and canine medicine. However, the relationship between vitamin D status and inflammation has not been previously investigated in cats. The aim of this study was to examine the relationship between serum 25(OH)D concentrations and leukocyte counts in hospitalised sick cats.METHODS: Serum 25(OH)D concentrations and haematology profiles were measured in 170 consecutive hospitalised sick cats. A binary logistical regression model examined the relationship between serum 25(OH)D concentration, age, sex, breed and neutrophil, monocyte, eosinophil and lymphocyte counts.RESULTS: Cats with neutrophilia had lower serum 25(OH)D concentrations than cats with neutrophil concentrations below the upper limit of the reference interval (RI). There were no differences in serum 25(OH)D concentrations in cats with monocyte, lymphocyte or eosinophil counts above their respective RI compared with cats with counts below the upper limit of the RI.CONCLUSIONS AND RELEVANCE: Hospitalised cats with a neutrophil count above the RI had lower vitamin D status. There is a need to establish whether lower vitamin D status is a cause or consequence of increased neutrophil counts.

U2 - 10.1177/1098612X15625454

DO - 10.1177/1098612X15625454

M3 - Article

C2 - 26795125

SN - 1098-612X

VL - 19

SP - 364

EP - 369

JO - Journal of Feline Medicine and Surgery

JF - Journal of Feline Medicine and Surgery

IS - 4

ER -

Relationship between vitamin D status and leukocytes in hospitalised cats

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