Projects per year
OBJECTIVES: The current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary. We used our well-characterised Sertoli cell ablation model in which we have empirically established the size of the Leydig cell population, to try to identify transcriptional biomarkers indicative of population size.
RESULTS: Following characterisation of the Leydig cell population after Sertoli cell ablation in neonatal life or adulthood, we identified Hsd3b1 transcript levels as a potential indicator of Leydig cell number with utility for informing decision-making on whether to engage in time-consuming stereological cell counting analysis.
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- 3 Finished
1/01/16 → 2/01/21
Integrating systems Biology adn transgenic technologies to unlock the secrets of sertoli cell development and function
Smith, L. & Freeman, T.
1/11/12 → 31/10/15
1/10/11 → 30/09/16