Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

M J Arends, E C Benton, K M McLaren, L A Stark, J A Hunter, C C Bird

Research output: Contribution to journalArticlepeer-review

Abstract

Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (
Original languageEnglish
Pages (from-to)722-8
Number of pages7
JournalBritish Journal of Cancer
Volume75
Issue number5
Publication statusPublished - 1997

Keywords

  • Adult
  • Aged
  • Anus Neoplasms
  • Cocarcinogenesis
  • DNA, Viral
  • Disease Susceptibility
  • Female
  • Genital Neoplasms, Female
  • Genital Neoplasms, Male
  • Humans
  • Immunohistochemistry
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Papillomaviridae
  • Risk Factors
  • Skin Neoplasms
  • Tumor Markers, Biological
  • Tumor Suppressor Protein p53

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