Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

M J Arends; E C Benton; K M McLaren; L A Stark; J A Hunter; C C Bird

Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

M J Arends, E C Benton, K M McLaren, L A Stark, J A Hunter, C C Bird

School of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (

Original language	English
Pages (from-to)	722-8
Number of pages	7
Journal	British Journal of Cancer
Volume	75
Issue number	5
Publication status	Published - 1997

Keywords / Materials (for Non-textual outputs)

Adult
Aged
Anus Neoplasms
Cocarcinogenesis
DNA, Viral
Disease Susceptibility
Female
Genital Neoplasms, Female
Genital Neoplasms, Male
Humans
Immunohistochemistry
Kidney Transplantation
Male
Middle Aged
Papillomaviridae
Risk Factors
Skin Neoplasms
Tumor Markers, Biological
Tumor Suppressor Protein p53

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Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy
BJC article available via europepmc open access link
Final published version, 1.27 MB

http://europepmc.org/articles/PMC2063341

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Arends, M. J., Benton, E. C., McLaren, K. M., Stark, L. A., Hunter, J. A., & Bird, C. C. (1997). Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. British Journal of Cancer, 75(5), 722-8. http://europepmc.org/articles/PMC2063341

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title = "Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy",

abstract = "Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (",

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author = "Arends, \{M J\} and Benton, \{E C\} and McLaren, \{K M\} and Stark, \{L A\} and Hunter, \{J A\} and Bird, \{C C\}",

year = "1997",

language = "English",

volume = "75",

pages = "722--8",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "5",

}

Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. / Arends, M J; Benton, E C; McLaren, K M et al.
In: British Journal of Cancer, Vol. 75, No. 5, 1997, p. 722-8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

AU - Arends, M J

AU - Benton, E C

AU - McLaren, K M

AU - Stark, L A

AU - Hunter, J A

AU - Bird, C C

PY - 1997

Y1 - 1997

N2 - Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (

AB - Renal allograft recipients (RARs) have a well-documented increased incidence of viral warts and cutaneous neoplasia, particularly those with long graft life and high sun exposure. A clinicopathological survey of 69 RARs in south-east Scotland, with follow-up periods of up to 28 years after transplantation, revealed marked variation in patient susceptibility to cutaneous malignancy with concomitant variation in HPV prevalence. Skin cancers were found in 34 patients. Eight patients showed high susceptibility [defined as more than four intraepidermal carcinomas (IECs) or invasive squamous cell carcinomas (SCCs)] 42 had intermediate susceptibility (1-3 IECs or SCCs, or >3 keratoses) and 18 had low susceptibility (

KW - Adult

KW - Aged

KW - Anus Neoplasms

KW - Cocarcinogenesis

KW - DNA, Viral

KW - Disease Susceptibility

KW - Female

KW - Genital Neoplasms, Female

KW - Genital Neoplasms, Male

KW - Humans

KW - Immunohistochemistry

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Papillomaviridae

KW - Risk Factors

KW - Skin Neoplasms

KW - Tumor Markers, Biological

KW - Tumor Suppressor Protein p53

M3 - Article

C2 - 9043031

SN - 0007-0920

VL - 75

SP - 722

EP - 728

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

ER -

Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy

Abstract

Keywords / Materials (for Non-textual outputs)

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