Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease

Alasdair G. Morgan; Michael J. Thrippleton; Michael Stringer; Ning Jin; Joanna M. Wardlaw; Ian Marshall

doi:10.3389/fpsyg.2023.1125038

Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease

Alasdair G. Morgan, Michael J. Thrippleton, Michael Stringer, Ning Jin, Joanna M. Wardlaw, Ian Marshall

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Frontiers in Psychology
Volume	14
DOIs	https://doi.org/10.3389/fpsyg.2023.1125038
Publication status	Published - 30 May 2023

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10.3389/fpsyg.2023.1125038

fpsyg-14-1125038Final published version, 2.35 MBLicence: Creative Commons: Attribution (CC-BY)

https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1125038/full

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@article{1f2d5eed5bcb4201aa8591832bfc038c,

title = "Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease",

author = "Morgan, {Alasdair G.} and Thrippleton, {Michael J.} and Michael Stringer and Ning Jin and Wardlaw, {Joanna M.} and Ian Marshall",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: AM and MRI scanning was funded by Medical Research Scotland, Siemens Healthcare, and the Medical Research Council through the UK Dementia Research Institute. Siemens Healthcare provided the work-in-progress 4D flow MRI pulse sequence and NJ reviewed the draft manuscript for technical accuracy. The funders were not otherwise involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. MT is funded by NHS Lothian Research and Development Office. MS is funded by the European Union Horizon 2020 project No. 666881, “SVDs@Target” and Fondation Leducq (ref no. 16 CVD 05). JW is funded by the UK Dementia Research Institute which receives its funding from DRI Ltd., funded by the UK Medical Research Council, Alzheimer{\textquoteright}s Society and Alzheimer{\textquoteright}s Research UK. The MR scanner was funded by the Wellcome Trust 104916/Z/14/Z, Dunhill Trust R380R/1114, Edinburgh and Lothians Health Foundation 2012/17, Muir Maxwell Research Fund, Edinburgh Imaging, and the University of Edinburgh. The authors acknowledge support from the Scottish Funding Council and Chief Scientist Office through the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE). The 4D flow sequence was provided by Siemens (NJ) as part of a technical research collaboration. The work is that of the authors and does not reflect the views of the funders. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Funding Information: NJ was employed by Siemens Medical Solutions USA, Inc. The authors declare that this study received funding from Siemens Healthcare, which had the following involvement in the study: provision of work-in-progress 4D flow MRI pulse sequence; NJ reviewed the draft manuscript for technical accuracy. While AM{\textquoteright}s PhD was partially funded by Siemens, all research was carried out without commercial influence. Funding Information: The authors gratefully acknowledge Grant Mair for his advice on locating and identifying intracranial vessels, Francesca Chappell for her statistical advice, Yulu Shi for the 2D PC-MRI processing methodology, the Edinburgh Imaging radiographers, Craig Buckley from Siemens Healthineers, and the participants who gave up their time to be scanned. Publisher Copyright: Copyright {\textcopyright} 2023 Morgan, Thrippleton, Stringer, Jin, Wardlaw and Marshall.",

year = "2023",

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doi = "10.3389/fpsyg.2023.1125038",

language = "English",

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TY - JOUR

T1 - Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease

AU - Morgan, Alasdair G.

AU - Thrippleton, Michael J.

AU - Stringer, Michael

AU - Jin, Ning

AU - Wardlaw, Joanna M.

AU - Marshall, Ian

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: AM and MRI scanning was funded by Medical Research Scotland, Siemens Healthcare, and the Medical Research Council through the UK Dementia Research Institute. Siemens Healthcare provided the work-in-progress 4D flow MRI pulse sequence and NJ reviewed the draft manuscript for technical accuracy. The funders were not otherwise involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. MT is funded by NHS Lothian Research and Development Office. MS is funded by the European Union Horizon 2020 project No. 666881, “SVDs@Target” and Fondation Leducq (ref no. 16 CVD 05). JW is funded by the UK Dementia Research Institute which receives its funding from DRI Ltd., funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. The MR scanner was funded by the Wellcome Trust 104916/Z/14/Z, Dunhill Trust R380R/1114, Edinburgh and Lothians Health Foundation 2012/17, Muir Maxwell Research Fund, Edinburgh Imaging, and the University of Edinburgh. The authors acknowledge support from the Scottish Funding Council and Chief Scientist Office through the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE). The 4D flow sequence was provided by Siemens (NJ) as part of a technical research collaboration. The work is that of the authors and does not reflect the views of the funders. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Funding Information: NJ was employed by Siemens Medical Solutions USA, Inc. The authors declare that this study received funding from Siemens Healthcare, which had the following involvement in the study: provision of work-in-progress 4D flow MRI pulse sequence; NJ reviewed the draft manuscript for technical accuracy. While AM’s PhD was partially funded by Siemens, all research was carried out without commercial influence. Funding Information: The authors gratefully acknowledge Grant Mair for his advice on locating and identifying intracranial vessels, Francesca Chappell for her statistical advice, Yulu Shi for the 2D PC-MRI processing methodology, the Edinburgh Imaging radiographers, Craig Buckley from Siemens Healthineers, and the participants who gave up their time to be scanned. Publisher Copyright: Copyright © 2023 Morgan, Thrippleton, Stringer, Jin, Wardlaw and Marshall.

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DO - 10.3389/fpsyg.2023.1125038

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SN - 1664-1078

VL - 14

JO - Frontiers in Psychology

JF - Frontiers in Psychology

ER -