Replication | DNA modification, restriction endonucleases: Type I enzymes

Gareth Roberts, David T. F. Dryden

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

The original genetic studies of type I DNA restriction and modification (R/M) enzymes demonstrated that some strains of Escherichia coli could restrict the ability of bacteriophage to propagate through the bacterial population. It was later shown that the surviving phage acquired an enzyme-specific methylation of DNA by type I R/M enzymes specific to the host bacterial strain, which was lost upon subsequent passage through different hosts. Purified type I restriction enzymes, which cut DNA into unpredictable pieces, have provided important molecular models for complex biological mechanisms.
Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry III
Publication statusPublished - 2 Aug 2021


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