Replication Proteins and Human Disease

Andrew P Jackson, Ronald A Laskey, Nicholas Coleman

Research output: Contribution to journalArticlepeer-review


In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.
Original languageEnglish
JournalCold Spring Harbor perspectives in biology
Publication statusPublished - 23 Jul 2013


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