Repo-Man-PP1: A link between chromatin remodelling and nuclear envelope reassembly

P. Vagnarelli; W.C. Earnshaw

doi:10.4161/nucl.19267

Repo-Man-PP1: A link between chromatin remodelling and nuclear envelope reassembly

P. Vagnarelli, W.C. Earnshaw

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner: this allows an orderly sequence of events to take place during mitotic exit. We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.

Original language	English
Pages (from-to)	138 - 142
Journal	Nucleus
Volume	3
Issue number	2
DOIs	https://doi.org/10.4161/nucl.19267
Publication status	Published - 1 Mar 2012

Keywords / Materials (for Non-textual outputs)

Nup 153
Protein Phosphatase 1
Repo-Man
importin beta
mitotic exit

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abstract = "Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner: this allows an orderly sequence of events to take place during mitotic exit. We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.",

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AU - Earnshaw, W.C.

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AB - Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner: this allows an orderly sequence of events to take place during mitotic exit. We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.

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KW - Protein Phosphatase 1

KW - Repo-Man

KW - importin beta

KW - mitotic exit

UR - https://www.scopus.com/pages/publications/84859541721

U2 - 10.4161/nucl.19267

DO - 10.4161/nucl.19267

M3 - Article

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ER -

Repo-Man-PP1: A link between chromatin remodelling and nuclear envelope reassembly

Abstract

Keywords / Materials (for Non-textual outputs)

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