Reprint: Good laboratory practice: preventing introduction of bias at the bench

Malcolm R. Macleod, Marc Fisher, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M. W. Bath, Alistair Buchan, H. Bart van der Worp, Richard J. Traystman, Kazuo Minematsu, Geoffrey A. Donnan, David W. Howells

Research output: Contribution to journalLiterature reviewpeer-review


As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
Publication statusPublished - Feb 2009

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