Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration

G A Gray; I S Toor; Rfp Castellan; M Crisan; M Meloni

doi:10.1016/j.cophys.2017.08.001

Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration

G A Gray, I S Toor, Rfp Castellan, M Crisan, M Meloni

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.

Original language	English
Pages (from-to)	46-51
Number of pages	6
Journal	Current opinion in physiology
Volume	1
Early online date	13 Dec 2017
DOIs	https://doi.org/10.1016/j.cophys.2017.08.001
Publication status	Published - Feb 2018

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1-s2.0-S2468867317300019-mainFinal published version, 520 KBLicence: CC BY

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title = "Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration",

abstract = "Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.",

author = "Gray, {G A} and Toor, {I S} and Rfp Castellan and M Crisan and M Meloni",

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AU - Toor, I S

AU - Castellan, Rfp

AU - Crisan, M

AU - Meloni, M

PY - 2018/2

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N2 - Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.

AB - Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.

U2 - 10.1016/j.cophys.2017.08.001

DO - 10.1016/j.cophys.2017.08.001

M3 - Review article

C2 - 29876531

VL - 1

SP - 46

EP - 51

JO - Current opinion in physiology

JF - Current opinion in physiology

ER -

Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration

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