Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

Jenna L Cash, Lucy V Norling, Mauro Perretti

Research output: Contribution to journalArticlepeer-review

Abstract

There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

Original languageEnglish
Pages (from-to)1186-92
Number of pages7
JournalDrug Discovery Today
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Animals
  • Anti-Inflammatory Agents
  • Drug Delivery Systems
  • Humans
  • Inflammation
  • Lipids
  • Peptides
  • Receptors, G-Protein-Coupled

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