Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

Jenna L Cash; Lucy V Norling; Mauro Perretti

doi:10.1016/j.drudis.2014.06.023

Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

Jenna L Cash, Lucy V Norling, Mauro Perretti

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

Original language	English
Pages (from-to)	1186-92
Number of pages	7
Journal	Drug Discovery Today
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/j.drudis.2014.06.023
Publication status	Published - Aug 2014

Keywords / Materials (for Non-textual outputs)

Animals
Anti-Inflammatory Agents
Drug Delivery Systems
Humans
Inflammation
Lipids
Peptides
Receptors, G-Protein-Coupled

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10.1016/j.drudis.2014.06.023

Cite this

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title = "Resolution of inflammation: targeting GPCRs that interact with lipids and peptides",

abstract = "There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).",

keywords = "Animals, Anti-Inflammatory Agents, Drug Delivery Systems, Humans, Inflammation, Lipids, Peptides, Receptors, G-Protein-Coupled",

author = "Cash, {Jenna L} and Norling, {Lucy V} and Mauro Perretti",

year = "2014",

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language = "English",

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pages = "1186--92",

journal = "Drug Discovery Today",

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AU - Cash, Jenna L

AU - Norling, Lucy V

AU - Perretti, Mauro

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N2 - There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

AB - There is a growing appreciation of the important role of resolution mediators in the successful termination of the inflammatory response. Here, we discuss the potential importance of the lipid and peptide proresolving mediators, in particular the resolvins and chemerin-derived peptides, which mediate their effects through specific G protein-coupled receptors (GPCRs).

KW - Animals

KW - Anti-Inflammatory Agents

KW - Drug Delivery Systems

KW - Humans

KW - Inflammation

KW - Lipids

KW - Peptides

KW - Receptors, G-Protein-Coupled

U2 - 10.1016/j.drudis.2014.06.023

DO - 10.1016/j.drudis.2014.06.023

M3 - Article

C2 - 24993159

SN - 1359-6446

VL - 19

SP - 1186

EP - 1192

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

Resolution of inflammation: targeting GPCRs that interact with lipids and peptides

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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