Respiratory Support in Bronchiolitis: Trial Evidence

Research output: Contribution to journalReview articlepeer-review


Acute viral lower respiratory tract infection is frequently associated with hypoxemia and respiratory distress, sometimes progressing to hypercarbia and respiratory failure. In recent years, trials have assessed the effects of oxygen supplementation and respiratory support with high-flow oxygen therapy. An oxygen saturation target of 90% is as safe and clinically effective as 94% in infants with bronchiolitis. Trials of high-flow humidified oxygen have demonstrated safety, but as yet poorly demarcated an appropriate place for use within the clinical course of the disease. Effective trials of continuous positive airway pressure are lacking and urgently required. The trials reported to date have highlighted the need for common outcomes in relation to treatment failure.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalAmerican journal of perinatology
Issue number6
Early online date25 Apr 2018
Publication statusE-pub ahead of print - 25 Apr 2018


  • Journal Article


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