Respiratory syncytial virus-associated hospitalisation in adults with 2 comorbidities in two European countries: a modelling study

PROMISE Investigators, Richard Osei-Yeboah, Caroline K Johannesen, Amanda Marie Egeskov-Cavling, Junru Chen, Toni Lehtonen, Arantxa Urchueguía Fornes, John Paget, Thea Kølsen Fischer, Xin Wang*, Harish Nair, Harry Campbell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background
Individuals with comorbidities are at increased risk of severe RSV infection. We estimated RSV-associated respiratory tract infection (RTI) hospitalisation among adults aged 45 years and older with comorbidities in Denmark and Scotland.
Methods
By analysing national hospital and virological data, we estimated the annual average number and rate of RSV-associated hospitalisations by seven selected comorbidities and ages during 2010-2018. We estimated rate ratios (RRs) of RSV-associated hospitalisation and 95% uncertainty ranges in comorbid adults versus the overall populations.
Results
In Danish adults (≥45 years), annual RSV-RTI hospitalisation rates ranged from 3.1 per 1000 adults with asthma to 19.4 per 1000 adults with chronic kidney disease (CKD). In Scotland, the annual rate ranged from 2.4 per 1000 adults with chronic liver disease (CLD) to 9.0 per 1000 adults with chronic obstructive pulmonary disease (COPD). In both countries, we found 2-4-fold increased risk of RSV hospitalisation in adults with COPD, ischemic heart disease (IHD), stroke and diabetes, 1.5-3-fold increased risk in adults with asthma, and 3-7-fold for those with CKD. RSV hospitalisation rates among adults aged 45-64 years with COPD, asthma, IHD or CKD were higher compared with the overall population.
Conclusion
The findings of this study provide important evidence for identifying risk groups and assisting health authorities in RSV vaccination policymaking.
Original languageEnglish
JournalThe Journal of Infectious Diseases
Early online date16 Nov 2023
DOIs
Publication statusE-pub ahead of print - 16 Nov 2023

Keywords / Materials (for Non-textual outputs)

  • Respiratory syncytial virus
  • adults
  • comorbidity
  • hospitalisation

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