Response of the physis to leg lengthening

S H Lee; G Szöke; H Simpson

Response of the physis to leg lengthening

S H Lee, G Szöke, H Simpson

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

UNLABELLED: The physeal response to limb lengthening by callotasis was investigated in an animal model by measuring 1) the growth rate using an oxytetracycline labelling technique, 2) histomorphological changes, and 3) proliferative cellular activity using bromodeoxyuridine. An osteotomy without lengthening stimulated growth at the physis. At 20% lengthening, regardless of the rate of distraction, no significant changes were detected. However, the growth rate was drastically reduced after 30% or more of lengthening and in 50% of cases there was evidence of premature closure of the distal growth plate.

CLINICAL RELEVANCE: Caution should be exercised in carrying out high percentages of lengthening of children's bones.

Original language	English
Pages (from-to)	339-43
Number of pages	5
Journal	Journal of Pediatric Orthopaedics B
Volume	10
Issue number	4
Publication status	Published - Oct 2001

Keywords / Materials (for Non-textual outputs)

Animals
Growth Plate
Models, Animal
Osteogenesis, Distraction
Rabbits
Tibia

Cite this

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title = "Response of the physis to leg lengthening",

abstract = "UNLABELLED: The physeal response to limb lengthening by callotasis was investigated in an animal model by measuring 1) the growth rate using an oxytetracycline labelling technique, 2) histomorphological changes, and 3) proliferative cellular activity using bromodeoxyuridine. An osteotomy without lengthening stimulated growth at the physis. At 20% lengthening, regardless of the rate of distraction, no significant changes were detected. However, the growth rate was drastically reduced after 30% or more of lengthening and in 50% of cases there was evidence of premature closure of the distal growth plate.CLINICAL RELEVANCE: Caution should be exercised in carrying out high percentages of lengthening of children's bones.",

keywords = "Animals, Growth Plate, Models, Animal, Osteogenesis, Distraction, Rabbits, Tibia",

author = "Lee, {S H} and G Sz{\"o}ke and H Simpson",

year = "2001",

month = oct,

language = "English",

volume = "10",

pages = "339--43",

journal = "Journal of Pediatric Orthopaedics B",

issn = "1060-152X",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Response of the physis to leg lengthening

AU - Lee, S H

AU - Szöke, G

AU - Simpson, H

PY - 2001/10

Y1 - 2001/10

N2 - UNLABELLED: The physeal response to limb lengthening by callotasis was investigated in an animal model by measuring 1) the growth rate using an oxytetracycline labelling technique, 2) histomorphological changes, and 3) proliferative cellular activity using bromodeoxyuridine. An osteotomy without lengthening stimulated growth at the physis. At 20% lengthening, regardless of the rate of distraction, no significant changes were detected. However, the growth rate was drastically reduced after 30% or more of lengthening and in 50% of cases there was evidence of premature closure of the distal growth plate.CLINICAL RELEVANCE: Caution should be exercised in carrying out high percentages of lengthening of children's bones.

AB - UNLABELLED: The physeal response to limb lengthening by callotasis was investigated in an animal model by measuring 1) the growth rate using an oxytetracycline labelling technique, 2) histomorphological changes, and 3) proliferative cellular activity using bromodeoxyuridine. An osteotomy without lengthening stimulated growth at the physis. At 20% lengthening, regardless of the rate of distraction, no significant changes were detected. However, the growth rate was drastically reduced after 30% or more of lengthening and in 50% of cases there was evidence of premature closure of the distal growth plate.CLINICAL RELEVANCE: Caution should be exercised in carrying out high percentages of lengthening of children's bones.

KW - Animals

KW - Growth Plate

KW - Models, Animal

KW - Osteogenesis, Distraction

KW - Rabbits

KW - Tibia

M3 - Article

C2 - 11727380

SN - 1060-152X

VL - 10

SP - 339

EP - 343

JO - Journal of Pediatric Orthopaedics B

JF - Journal of Pediatric Orthopaedics B

IS - 4

ER -

Response of the physis to leg lengthening

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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