Response to Comment on "Human-Specific Gain of Function in a Developmental Enhancer"

Shyam Prabhakar, Axel Visel, Jennifer A. Akiyama, Malak Shoukry, Keith D. Lewis, Amy Holt, Ingrid Plajzer-Frick, Harris Morrison, David R. FitzPatrick, Veena Afzal, Len A. Pennacchio, Edward M. Rubin, James P. Noonan

Research output: Contribution to journalEditorialpeer-review


Duret and Galtier argue that human- specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGC events genomewide and assessing the effect of recombination rates on human- accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT --> GC substitution bias can coexist with positive selection.

Original languageEnglish
Pages (from-to)-
Number of pages2
Issue number5915
Publication statusPublished - 6 Feb 2009

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