Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

Tineke Grent-‘t-Jong, Joachim Gross, Jozien Goense, Michael Wibral, Ruchika Gajwani, Andrew I Gumley, Stephen Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Tobias Navarro Schröder, Dagmar Koethe, F. Markus Leweke, Wolf Singer, Peter J. Uhlhaas

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
Original languageEnglish
Article numbere37799
Pages (from-to)1-19
Number of pages19
Early online date27 Sept 2018
Publication statusPublished - 27 Sept 2018

Keywords / Materials (for Non-textual outputs)

  • schizophrenia
  • magnetoencephalograpghy
  • Gamma-Band
  • source-reconstruction
  • E/I-Balance
  • glutamate
  • GABA
  • MR-Spectroscopy


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