Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation lschaemic stroke

M. R. Macleod*, S. M. Davis, P. J. Mitchell, R. P. Gerraty, G. Fitt, G. J. Hankey, E. G. Stewart-Wynne, D. Rosen, J. J. McNeil, C. F. Bladin, B. R. Chambers, G. K. Herkes, D. Young, G. A. Donnan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Patients with ischaemic stroke due to occlusion of the basilar or vertebral arteries may develop a rapid deterioration in neurological status leading to coma and often to death. While intra-arterial thrombolysis may be used in this context, no randomised controlled data exist to support its safety or efficacy. Methods: Randomised controlled trial of intra-arterial urokinase within 24 h of symptom onset in patients with stroke and angiographic evidence of posterior circulation vascular occlusion. Results: Sixteen patients were randomised, and there was some imbalance between groups, with more severe strokes occurring in the treatment arm. A good outcome was observed in 4 of 8 patients who received intra-arterial urokinase compared with 1 of 8 patients in the control group. Conclusions: These results support the need for a large-scale study to establish the efficacy of intra-arterial thrombolysis for acute basilar artery occlusion.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalCerebrovascular diseases
Volume20
Issue number1
DOIs
Publication statusPublished - 2005

Keywords

  • Intra-arterial thrombolysis
  • Posterior circulation stroke
  • Randomised controlled trial

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