Results of allergen-specific immunotherapy in atopic dogs with Malassezia hypersensitivity- a retrospective study of 16 cases

Liselotte Aberg, Eva Varjonen, Susanne Ahman

Research output: Contribution to journalArticlepeer-review

Abstract

Background- Hypersensitivity reactions to Malassezia spp have been shown to occur in both people and dogs suffering from atopic dermatitis (AD) and to cause exacerbation of clinical signs. Improvement of clinical signs following use of antifungal medication is seen with both Malassezia overgrowth (MOG) or Malassezia hypersensitivity (MHS). Allergen-specific immunotherapy (ASIT) is considered a safe and effective treatment option for management of canine atopic dermatitis (CAD). Adverse effects are considered rare. To the authors’ knowledge this is the first retrospective study reporting on the safety and efficacy of ASIT in atopic dogs with MHS.


Objectives- To study the efficacy and safety of ASIT containing only Malassezia extracts in mono-sensitized dogs.


Animals- 16 client owned dogs diagnosed with Malassezia hypersensitivity (MHS) and treated with ASIT.


Methods- A retrospective review of medical records of atopic dogs diagnosed with MHS, mono-sensitized for Malassezia allergens on intradermal test and treated with ASIT for more than 10 months. Efficacy was measured by decreasing use of anti-inflammatory and antifungal medication by 50 % or more and by decreasing pruritus by 50 % or more as assessed by owners.


Results- Good response to SCIT was seen in 9/16 cases (56%) with both a reduction in use of anti-inflammatory and antifungal medication as well as a reduction in pruritus by 50% or more. No adverse effects were reported.


Conclusion- Allergen-specific immunotherapy is a safe treatment for dogs with Malassezia hypersensitivity. Efficacy of Malassezia immunotherapy corresponds well to the results of previous studies of immunotherapy with other environmental allergens.
Original languageEnglish
JournalVeterinary Dermatology
Early online date26 Jul 2017
DOIs
Publication statusE-pub ahead of print - 26 Jul 2017

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