Retinal Biomarker Discovery for Dementia in an Elderly Diabetic Population

VAMPIRE project, Vascular Assessment and Measurement Platform for Images of the REtina

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Dementia is a devastating disease, and has severe implications on affected individuals, their family and wider society. A growing body of literature is studying the association of retinal microvasculature measurement with dementia. We present a pilot study testing the strength of groups of conventional (semantic) and texture-based (non-semantic) measurements extracted from retinal fundus camera images to classify patients with and without dementia. We performed a 500-trial bootstrap analysis with regularized logistic regression on a cohort of 1,742 elderly diabetic individuals (median age 72.2). Age was the strongest predictor for this elderly cohort. Semantic retinal measurements featured in up to 81% of the bootstrap trials, with arterial caliber and optic disk size chosen most often, suggesting that they do complement age when selected together in a classifier. Textural features were able to train classifiers that match the performance of age, suggesting they are potentially a rich source of information for dementia outcome classification
Original languageEnglish
Title of host publicationInternational Workshop on Ophthalmic Medical Image Analysis
PublisherSpringer
Pages 150-158
Publication statusPublished - 9 Sep 2017

Publication series

NameLNCS
Volume10554

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