Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

Sarah McGrory; Lucia Ballerini; Judith Okely; Stuart Ritchie; Fergus Doubal; Alex S. F. Doney; John Starr; Thomas MacGillivray; Emanuele Trucco; Joanna Wardlaw; Ian Deary

doi:10.1016/j.dadm.2019.04.012

Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

Sarah McGrory, Lucia Ballerini, Judith Okely, Stuart Ritchie, Fergus Doubal, Alex S. F. Doney, John Starr, Thomas MacGillivray, Emanuele Trucco, Joanna Wardlaw, Ian Deary

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change.
METHODS: Retinal images from a narrow-age cohort were analysed using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed and crystallized cognitive abilities at mean ages 73, 76 and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.
RESULTS: Almost all associations were non-significant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73.
DISCUSSION: Our null findings suggest that the quantitative retinal parameters applied here are not significantly associated with cognitive functioning or cognitive change.

Original language	English
Pages (from-to)	500-509
Number of pages	10
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	11
Early online date	10 Jul 2019
DOIs	https://doi.org/10.1016/j.dadm.2019.04.012
Publication status	Published - Dec 2019

Keywords

retinal imaging
cognitive change
longitudinal study

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McGroryEtalA&D2019RetinalMicrovascularFeaturesAmdCognitiveChangFinal published version, 584 KBLicence: Creative Commons: Attribution (CC-BY)

The Disconnected Mind Phase 3
Cox, S. & Deary, I.
UK-based charities
1/04/16 → 31/03/23
Project: Research
RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Wardlaw, J.
1/09/13 → 31/08/19
Project: Research

Cite this

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title = "Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936",

abstract = "INTRODUCTION: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. METHODS: Retinal images from a narrow-age cohort were analysed using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed and crystallized cognitive abilities at mean ages 73, 76 and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.RESULTS: Almost all associations were non-significant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. DISCUSSION: Our null findings suggest that the quantitative retinal parameters applied here are not significantly associated with cognitive functioning or cognitive change.",

keywords = "retinal imaging, cognitive change, longitudinal study",

author = "Sarah McGrory and Lucia Ballerini and Judith Okely and Stuart Ritchie and Fergus Doubal and Doney, {Alex S. F.} and John Starr and Thomas MacGillivray and Emanuele Trucco and Joanna Wardlaw and Ian Deary",

year = "2019",

month = dec,

doi = "10.1016/j.dadm.2019.04.012",

language = "English",

volume = "11",

pages = "500--509",

journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",

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TY - JOUR

T1 - Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

AU - McGrory, Sarah

AU - Ballerini, Lucia

AU - Okely, Judith

AU - Ritchie, Stuart

AU - Doubal, Fergus

AU - Doney, Alex S. F.

AU - Starr, John

AU - MacGillivray, Thomas

AU - Trucco, Emanuele

AU - Wardlaw, Joanna

AU - Deary, Ian

PY - 2019/12

Y1 - 2019/12

N2 - INTRODUCTION: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. METHODS: Retinal images from a narrow-age cohort were analysed using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed and crystallized cognitive abilities at mean ages 73, 76 and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.RESULTS: Almost all associations were non-significant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. DISCUSSION: Our null findings suggest that the quantitative retinal parameters applied here are not significantly associated with cognitive functioning or cognitive change.

AB - INTRODUCTION: We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. METHODS: Retinal images from a narrow-age cohort were analysed using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospatial, processing speed and crystallized cognitive abilities at mean ages 73, 76 and 79 years. We applied multivariate growth curve models to test the association between retinal vascular measurements with cognitive abilities and their changes.RESULTS: Almost all associations were non-significant. In our most parsimonious model, venular asymmetry factor was associated with speed at age 73. DISCUSSION: Our null findings suggest that the quantitative retinal parameters applied here are not significantly associated with cognitive functioning or cognitive change.

KW - retinal imaging

KW - cognitive change

KW - longitudinal study

U2 - 10.1016/j.dadm.2019.04.012

DO - 10.1016/j.dadm.2019.04.012

M3 - Article

C2 - 31338413

VL - 11

SP - 500

EP - 509

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

SN - 2352-8729

ER -

Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

Abstract

Keywords

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Projects

The Disconnected Mind Phase 3

RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Cite this