Retrospective study of prion-protein accumulation in tonsil and appendix tissues

J W Ironside, D A Hilton, A Ghani, N J Johnston, L Conyers, L M McCardle, D Best

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

Original languageEnglish
Pages (from-to)1693-4
Number of pages2
JournalThe Lancet
Issue number9216
Publication statusPublished - 13 May 2000

Keywords / Materials (for Non-textual outputs)

  • Appendix
  • Creutzfeldt-Jakob Syndrome
  • Cross-Sectional Studies
  • Great Britain
  • Humans
  • Incidence
  • Palatine Tonsil
  • Prions
  • Retrospective Studies


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