Retrospective study of prion-protein accumulation in tonsil and appendix tissues

J W Ironside; D A Hilton; A Ghani; N J Johnston; L Conyers; L M McCardle; D Best

doi:10.1016/S0140-6736(00)02243-1

Retrospective study of prion-protein accumulation in tonsil and appendix tissues

J W Ironside, D A Hilton, A Ghani, N J Johnston, L Conyers, L M McCardle, D Best

School of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

Original language	English
Pages (from-to)	1693-4
Number of pages	2
Journal	The Lancet
Volume	355
Issue number	9216
DOIs	https://doi.org/10.1016/S0140-6736(00)02243-1
Publication status	Published - 13 May 2000

Keywords / Materials (for Non-textual outputs)

Appendix
Creutzfeldt-Jakob Syndrome
Cross-Sectional Studies
Great Britain
Humans
Incidence
Palatine Tonsil
Prions
Retrospective Studies

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10.1016/S0140-6736(00)02243-1

Cite this

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title = "Retrospective study of prion-protein accumulation in tonsil and appendix tissues",

abstract = "To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.",

keywords = "Appendix, Creutzfeldt-Jakob Syndrome, Cross-Sectional Studies, Great Britain, Humans, Incidence, Palatine Tonsil, Prions, Retrospective Studies",

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AU - Ironside, J W

AU - Hilton, D A

AU - Ghani, A

AU - Johnston, N J

AU - Conyers, L

AU - McCardle, L M

AU - Best, D

PY - 2000/5/13

Y1 - 2000/5/13

N2 - To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

AB - To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

KW - Appendix

KW - Creutzfeldt-Jakob Syndrome

KW - Cross-Sectional Studies

KW - Great Britain

KW - Humans

KW - Incidence

KW - Palatine Tonsil

KW - Prions

KW - Retrospective Studies

U2 - 10.1016/S0140-6736(00)02243-1

DO - 10.1016/S0140-6736(00)02243-1

M3 - Article

C2 - 10905247

SN - 0140-6736

VL - 355

SP - 1693

EP - 1694

JO - The Lancet

JF - The Lancet

IS - 9216

ER -

Retrospective study of prion-protein accumulation in tonsil and appendix tissues

Abstract

Keywords / Materials (for Non-textual outputs)

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