Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer

Mark S Duxbury, Hiromichi Ito, Eric Benoit, Michael J Zinner, Stanley W Ashley, Edward E Whang

Research output: Contribution to journalArticlepeer-review

Abstract

Ribonucleotide reductase M2 subunit (RRM2) overexpression enhances tumor chemoresistance and cellular invasiveness. We hypothesized that the RNA interference (RNAi) induced by retrovirally delivered small interfering RNA (siRNA) would sensitize pancreatic adenocarcinoma cells to gemcitabine and attenuate their invasive potential.
Original languageEnglish
Pages (from-to)261-9
Number of pages9
JournalSurgery
Volume136
Issue number2
DOIs
Publication statusPublished - 2004

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