REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES

E C  HOLMES; S  NEE; A  RAMBAUT; G P  GARNETT; P H  HARVEY

REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES

E C HOLMES, S NEE, A RAMBAUT, G P GARNETT, P H HARVEY

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to trace the dynamics of viral transmission within populations. Case studies document the worldwide spread of Human Immunodeficiency Virus type 1 (HIV-1) and hepatitis C virus (HCV). Despite similarities between these viruses, especially in their transmission routes, they are shown to have very different epidemiological histories. A possible reason for the difference is that HCV has coexisted longer with human populations.

Original language	English
Pages (from-to)	33-40
Number of pages	8
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	349
Issue number	1327
Publication status	Published - 29 Jul 1995

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title = "REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES",

abstract = "Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to trace the dynamics of viral transmission within populations. Case studies document the worldwide spread of Human Immunodeficiency Virus type 1 (HIV-1) and hepatitis C virus (HCV). Despite similarities between these viruses, especially in their transmission routes, they are shown to have very different epidemiological histories. A possible reason for the difference is that HCV has coexisted longer with human populations.",

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AU - GARNETT, G P

AU - HARVEY, P H

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AB - Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to trace the dynamics of viral transmission within populations. Case studies document the worldwide spread of Human Immunodeficiency Virus type 1 (HIV-1) and hepatitis C virus (HCV). Despite similarities between these viruses, especially in their transmission routes, they are shown to have very different epidemiological histories. A possible reason for the difference is that HCV has coexisted longer with human populations.

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JF - Philosophical Transactions of the Royal Society B: Biological Sciences

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ER -

REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES

Abstract

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