Review Canine Tuberculosis - An Emerging Concern

Emi N Barker; Conor O'Halloran; Danièlle A Gunn-Moore

doi:10.1016/j.tvjl.2024.106111

Review Canine Tuberculosis - An Emerging Concern

Emi N Barker, Conor O'Halloran, Danièlle A Gunn-Moore

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Review article › peer-review

Abstract

Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result. Optimised triple antimicrobial protocols offer an excellent chance of a successful outcome in dogs where treatment can be considered and is attempted. In this review, the clinical presentation, diagnosis, treatment, and prognosis of canine tuberculosis are discussed.

Original language	English
Article number	106111
Pages (from-to)	1-12
Number of pages	12
Journal	The Veterinary Journal
Volume	305
Early online date	9 Apr 2024
DOIs	https://doi.org/10.1016/j.tvjl.2024.106111
Publication status	Published - Jun 2024

Keywords / Materials (for Non-textual outputs)

Interferon-gamma release assay
Mycobacterium bovis
Treatment
Tuberculosis Zoonosis

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10.1016/j.tvjl.2024.106111

1-s2.0-S1090023324000509-mainFinal published version, 5.71 MBLicence: CC BY

Cite this

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title = "Review Canine Tuberculosis - An Emerging Concern",

abstract = "Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result. Optimised triple antimicrobial protocols offer an excellent chance of a successful outcome in dogs where treatment can be considered and is attempted. In this review, the clinical presentation, diagnosis, treatment, and prognosis of canine tuberculosis are discussed.",

keywords = "Interferon-gamma release assay, Mycobacterium bovis, Treatment, Tuberculosis Zoonosis",

author = "Barker, {Emi N} and Conor O'Halloran and Gunn-Moore, {Dani{\`e}lle A}",

note = "Copyright {\textcopyright} 2024. Published by Elsevier Ltd.",

year = "2024",

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doi = "10.1016/j.tvjl.2024.106111",

language = "English",

volume = "305",

pages = "1--12",

journal = "The Veterinary Journal",

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T1 - Review Canine Tuberculosis - An Emerging Concern

AU - Barker, Emi N

AU - O'Halloran, Conor

AU - Gunn-Moore, Danièlle A

PY - 2024/6

Y1 - 2024/6

N2 - Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result. Optimised triple antimicrobial protocols offer an excellent chance of a successful outcome in dogs where treatment can be considered and is attempted. In this review, the clinical presentation, diagnosis, treatment, and prognosis of canine tuberculosis are discussed.

AB - Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result. Optimised triple antimicrobial protocols offer an excellent chance of a successful outcome in dogs where treatment can be considered and is attempted. In this review, the clinical presentation, diagnosis, treatment, and prognosis of canine tuberculosis are discussed.

KW - Interferon-gamma release assay

KW - Mycobacterium bovis

KW - Treatment

KW - Tuberculosis Zoonosis

U2 - 10.1016/j.tvjl.2024.106111

DO - 10.1016/j.tvjl.2024.106111

M3 - Review article

C2 - 38604331

SN - 1090-0233

VL - 305

SP - 1

EP - 12

JO - The Veterinary Journal

JF - The Veterinary Journal

M1 - 106111

ER -

Review Canine Tuberculosis - An Emerging Concern

Abstract

Keywords / Materials (for Non-textual outputs)

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