Review: Pathogenesis of canine atopic dermatitis: skin barrier and host–micro-organism interaction

Domenico Santoro, Rosanna Marsella, Cherie M. Pucheu-Haston*, Eisenschenk Melissa, Tim Nuttall, Petra Bizikova

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Background
Canine atopic dermatitis (AD) is a common, genetically predisposed, inflammatory and pruritic skin disease. The pathogenesis of canine AD is incompletely understood.

Objectives
The aim of this review is to provide an in-depth update on the involvement of skin barrier and host–microbiome interaction in the pathogenesis of canine AD.

Methods
Online citation databases and abstracts from international meetings were searched for publications related to skin barrier and host–microbiome interaction (e.g. bacteria, yeast, antimicrobial peptides).

Results
A total of 126 publications were identified. This review article focuses on epidermal barrier dysfunction and the interaction between cutaneous microbes (bacteria and yeasts) and the host (antimicrobial peptides). Epidemiological updates on the presence of pathogenic organisms and canine AD are also provided.

Conclusions and clinical importance
Major advances have been made in the investigation of skin barrier dysfunction in canine AD, although many questions still remain. Skin barrier dysfunction and host–microbiome interactions are emerging as primary alterations in canine AD. Based on this review, it is clear that future studies focused on the development of drugs able to restore the skin barrier and increase the natural defences against pathogenic organisms are needed.
Original languageEnglish
Pages (from-to)84–e25
Number of pages12
JournalVeterinary Dermatology
Volume26
Issue number2
Early online date13 Feb 2015
DOIs
Publication statusPublished - Apr 2015

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