Ribosomal RNA processing in saccharomyces cerevisiae

Rob Van Nues, Jaap Venema, R.J. Planta, Hendrik A. Raué

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Ribosome biogenesis in eukaryotic cells requires an intricate interplay between a large number of molecules. In the course of this process some 80 ribosomal proteins (r-proteins) have to assemble in an ordered fashion with the four rRNA molecules, which themselves are formed by stepwise maturation of primary transcripts produced by two different RNA polymerases. rRNA processing and r-protein assembly occur concomitantly and are interdependent. Furthermore, a growing number of non-ribosomal components, both proteins and ribonucleoprotein (RNP) particles, is being identified, that are required in trans for the correct and efficient formation of eukaryotic ribosomes. Because of its accessibility to genetic and physiological manipulation, the yeast Saccharomyces cerevisiae has become one of the most popular organisms for studying eukaryotic ribosome biogenesis. In this Chapter we will discuss recent progress in the identification of both cis-acting elements and trans-acting factors involved in the formation of the mature 17S, 26S and 5.8S rRNA species in yeast.
Original languageEnglish
Title of host publicationThe Translational Apparatus
Subtitle of host publicationStructure, Function, Regulation, Evolution
EditorsKnud H. Nierhaus, Francois Franceschi, Alap R. Subramanian, Volker A. Erdmann, Brigitte Wittmann-Liebold
PublisherPlenum Press
ISBN (Print)0-306-44538-7
Publication statusPublished - 1993
EventThe Translational Apparatus - Berlin, Germany
Duration: 31 Oct 19925 Nov 1992


ConferenceThe Translational Apparatus


  • rRNA processing
  • rDNA Unit
  • external transcribe space
  • 29SB molecule
  • ITS1 ITS2


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